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KMID : 1035220210130020064
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Korean Journal of Neuromuscular Disorders
2021 Volume.13 No. 2 p.64 ~ p.66
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Statin-Induced Immune-Mediated Necrotizing Myopathy with Anti-HMGCR Antibody
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Lee Jeong-Jae
Kim Eui-Hyun
Kim Na-Hee
Park Hyung-Jun
Kim Yoo-Hwan
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Abstract
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Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR) antibody related immune-mediated necrotizing myopathy (IMNM) are usually associated with statin use. The disease has features of persistent muscle weakness and creatine kinase (CK) elevation after statin discontinuation. This report describes a 65-year-old female taking atorvastatin, presenting with both proximal lower extremity weakness. IMNM feature were detected on muscle biopsy and high anti-HMGCR autoantibody titer on enzyme-linked immunosorbent assay (ELISA). This patient was treated with corticosteroid. Muscle weakness and CK are improved after immunosuppressive therapy.
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KEYWORD
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Immune-mediated necrotizing myopathy, Anti-HMGCR, Statin
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